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  • Title: Bioavailability of water-soluble CoQ10 in beagle dogs.
    Author: Prosek M, Butinar J, Lukanc B, Fir MM, Milivojevic L, Krizman M, Smidovnik A.
    Journal: J Pharm Biomed Anal; 2008 Aug 05; 47(4-5):918-22. PubMed ID: 18495407.
    Abstract:
    The bioavailability of a novel water-soluble inclusion complex of CoQ10, prepared in our laboratory was determined and compared with the bioavailability of commercially available oil-based form of CoQ10. Experimental work consisted of single dose comparative bioavailability study on seven beagle dogs, with a 14-day washout period between treatments. Identification and quantification of CoQ10 was done with HPLC-MS method using positive APCI ionization and SIM mode, M+ m/z 863.4. The bioavailability results confirm that the water-soluble formulation has nearly three times higher AUC(0-48 h), two times higher Cmax, and Tmax is shortened from 6 to 4 h.
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