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  • Title: Radiation doses and risks from internal emitters.
    Author: Harrison J, Day P.
    Journal: J Radiol Prot; 2008 Jun; 28(2):137-59. PubMed ID: 18495991.
    Abstract:
    This review updates material prepared for the UK Government Committee Examining Radiation Risks from Internal Emitters (CERRIE) and also refers to the new recommendations of the International Commission on Radiological Protection (ICRP) and other recent developments. Two conclusions from CERRIE were that ICRP should clarify and elaborate its advice on the use of its dose quantities, equivalent and effective dose, and that more attention should be paid to uncertainties in dose and risk estimates and their implications. The new ICRP recommendations provide explanations of the calculation and intended purpose of the protection quantities, but further advice on their use would be helpful. The new recommendations refer to the importance of understanding uncertainties in estimates of dose and risk, although methods for doing this are not suggested. Dose coefficients (Sv per Bq intake) for the inhalation or ingestion of radionuclides are published as reference values without uncertainty. The primary purpose of equivalent and effective dose is to enable the summation of doses from different radionuclides and from external sources for comparison with dose limits, constraints and reference levels that relate to stochastic risks of whole-body radiation exposure. Doses are calculated using defined biokinetic and dosimetric models, including reference anatomical data for the organs and tissues of the human body. Radiation weighting factors are used to adjust for the different effectiveness of different radiation types, per unit absorbed dose (Gy), in causing stochastic effects at low doses and dose rates. Tissue weighting factors are used to take account of the contribution of individual organs and tissues to overall detriment from cancer and hereditary effects, providing a simple set of rounded values chosen on the basis of age- and sex-averaged values of relative detriment. While the definition of absorbed dose has the scientific rigour required of a basic physical quantity, the same is not true of the ICRP protection quantities equivalent and effective dose (i.e. those measured in sieverts). The ICRP quantities are intended for practical application in radiological protection and the choice of radiation and tissue weighting factors used in their calculation involves simplifying assumptions regarded as acceptable for this purpose. Best estimates of doses and risks to individuals and specific population groups may be calculated using ICRP biokinetic and dosimetric approaches, but would require the use of best available information on RBE and age-, sex- and population-specific risk factors. Consideration of uncertainties is important in applications such as the assessment of the probability of cancer causation for an individual and in estimating doses in epidemiological studies. While the ICRP system of protection does not take explicit account of uncertainties, an understanding of the various contributions to uncertainty can be seen to be of value when making judgments on the optimisation of protection.
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