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  • Title: Synthesis of enantiomerically pure 1,2,3,4-tetrahydro-beta-carbolines and N-acyl-1-aryl ethylamines by rhodium-catalyzed hydrogenation.
    Author: Enthaler S, Erre G, Junge K, Addis D, Kadyrov R, Beller M.
    Journal: Chem Asian J; 2008 Jul 07; 3(7):1104-10. PubMed ID: 18496827.
    Abstract:
    The rhodium-catalyzed asymmetric hydrogenation of different enamides, in particular, dihydro-beta-carboline derivates, was investigated in the presence of chiral phosphorus ligands. Enantioselectivities of up to 99 % ee were obtained after ligand screening and optimization of the reaction conditions. The scope and limitation of the catalysts were shown in the synthesis of optically active tetrahydro-beta-carbolines and other benchmark N-acyl-1-aryl ethylamines.
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