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  • Title: Type I immediate hypersensitivity reaction to cyanocobalamin but not hydroxycobalamin.
    Author: Moloney FJ, Hughes R, O'Shea D, Kirby B.
    Journal: Clin Exp Dermatol; 2008 Jul; 33(4):412-4. PubMed ID: 18498413.
    Abstract:
    We report a case of a 42-year-old woman with a background of autoimmune polyglandular syndrome, who developed a type I immediate hypersensitivity reaction to intramuscular cyanocobalamin. Intradermal testing showed a positive reaction to cyanocobalamin. The patient was subsequently treated with intramuscular hydroxycobalamin after negative intradermal testing to this alternative B(12) compound. A review of previously described cases of hypersensitivity to either compound provides a rationale for the management of this rare but serious side-effect.
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