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  • Title: Sleep rebound attenuates context-dependent behavioural sensitization induced by amphetamine.
    Author: Calzavara MB, Andersen ML, Fukushiro DF, Lopez GB, Abílio VC, Tufik S, Frussa-Filho R.
    Journal: Prog Neuropsychopharmacol Biol Psychiatry; 2008 Jul 01; 32(5):1277-82. PubMed ID: 18499322.
    Abstract:
    We have recently demonstrated that paradoxical sleep deprivation (PSD) potentiates the induction of amphetamine (AMPH)-induced behavioural sensitization by increasing its conditioned component. In the present study, the effects of sleep rebound (induced by 24 h recovery period from PSD) were studied on AMPH-induced behavioural sensitization. Sleep rebound attenuated the acute locomotor-stimulating effect of AMPH. AMPH-induced behavioural sensitization was context-specific and was also attenuated by sleep rebound. These results strengthen the notion that sleep conditions can influence AMPH-induced behavioural sensitization.
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