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  • Title: Effects of nerve crush and transection on mRNA levels for nerve growth factor receptor in the rat facial motoneurons.
    Author: Saika T, Senba E, Noguchi K, Sato M, Yoshida S, Kubo T, Matsunaga T, Tohyama M.
    Journal: Brain Res Mol Brain Res; 1991 Jan; 9(1-2):157-60. PubMed ID: 1850072.
    Abstract:
    We found that the level of nerve growth factor receptor (NGF-R) mRNA in facial motoneurons was increased after both facial nerve crushing and transection by means of in situ hybridization histochemistry. The increased level of NGF-R mRNA was maintained for at least 8 weeks after facial nerve transection, while facial nerve crushing caused only a transient increase. Thus, expression of NGF-R mRNA paralleled the axonal regeneration process. In addition, the increase of NGF-R mRNA with crushing was more pronounced than with transection from the 3rd to the 14th day after the insult.
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