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  • Title: [Risk factors of preeclampsia in single pregnancy].
    Author: Merviel P, Touzart L, Deslandes V, Delmas M, Coicaud M, Gondry J.
    Journal: J Gynecol Obstet Biol Reprod (Paris); 2008 Sep; 37(5):477-82. PubMed ID: 18501532.
    Abstract:
    OBJECTIVES: Study of the clinical risk factors of preeclampsia during a single pregnancy. MATERIALS AND METHODS: Retrospective case-control study during five years. RESULTS: One hundred and eighty-eight cases of preeclampsia have been studied, with 147 called severe (78.2%). We find as risk factors: first pregnancy (OR=2.11; IC 95% [1.30-3.35]), primiparity (OR=2.67; IC 95% [1.67-4.29]), primipaternity (OR=3.55; IC 95% [2.13-5.83], maternal overweight (OR=2.50; IC 95% [1.55-4.05]), personal history of preeclampsia (OR=8.12; IC 95% [2.37-45.65]), personal history of hypertension (OR=2.77; IC 95% [1.01-7.99]), familial history of preeclampsia (OR=1.04; IC 95% [1.01-1.08]), familial history of hypertension at the first step (OR=2.61; IC 95% [1.32-5.47]). Two elements have been found as protected: tobacco before pregnancy (OR=0.51; IC 95% [0.36-0.85]), tobacco during pregnancy (OR=0.52; IC 95% [0.30-0.92]). CONCLUSION: Preeclampsia is responsible of a high maternal and fetal morbidity. The risk factors are widespread, the only use of them is not enough to determine the individual risk. A second step could be to determine if biological markers are better than clinical factors.
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