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  • Title: IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.
    Author: Buckley GM, Fosbeary R, Fraser JL, Gowers L, Higueruelo AP, James LA, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V.
    Journal: Bioorg Med Chem Lett; 2008 Jun 15; 18(12):3656-60. PubMed ID: 18501603.
    Abstract:
    Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines was explored.
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