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  • Title: Novel isocyanide-based four-component reaction: a facile synthesis of fully substituted 3,4-dihydrocoumarin derivatives.
    Author: Shaabani A, Soleimani E, Rezayan AH, Sarvary A, Khavasi HR.
    Journal: Org Lett; 2008 Jun 19; 10(12):2581-4. PubMed ID: 18503292.
    Abstract:
    A novel isocyanide-based four-component reaction between a 2-hydroxybenzaldehyde, Meldrum's acid, an isocyanide, and an aromatic or an aliphatic alcohol efficiently provide 3,4-dihydrocoumarin derivatives in good to excellent yields without using any catalyst or activation. The reaction can be carried out as a simple one-pot protocol at room temperature.
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