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  • Title: Vincristine-induced peripheral neuropathy in a dog.
    Author: Hamilton TA, Cook JR, Braund KG, Morrison WB, Mehta JR.
    Journal: J Am Vet Med Assoc; 1991 Feb 15; 198(4):635-8. PubMed ID: 1850399.
    Abstract:
    A 12-year-old spayed Golden Retriever with mycosis fungoides was treated by use of a chemotherapy protocol that included vincristine. After 16 weekly vincristine injections, the dog began to have signs of peripheral neuropathy. Results of electromyographic examination were consistent with muscle denervation, and motor nerve conduction velocity was depressed. Histologic examination of a common peroneal nerve biopsy specimen revealed severe nerve fiber degeneration. Clinical response and pathologic evidence of improvement were observed after the drug had been discontinued for 2.5 months.
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