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  • Title: A prospective comparison of random urine protein-creatinine ratio vs 24-hour urine protein in women with preeclampsia.
    Author: Aggarwal N, Suri V, Soni S, Chopra V, Kohli HS.
    Journal: Medscape J Med; 2008 Apr 22; 10(4):98. PubMed ID: 18504482.
    Abstract:
    OBJECTIVE: To assess the diagnostic accuracy of random urine protein-creatinine ratio for the prediction of significant proteinuria in patients with preeclampsia. STUDY DESIGN: 155 pregnant patients diagnosed to have hypertension in late pregnancy were instructed to collect urine during a 24-hour period. Protein-creatinine ratio was evaluated in a random urinary specimen. Out of these, 120 patients fulfilled the inclusion criteria. The predictive value of the random urinary protein-creatinine ratio for the diagnosis of significant proteinuria was estimated by using a 300-mg protein level within the collected 24-hour urine as the gold standard. RESULTS: 104 patients (86.67%) had significant proteinuria. There was significant association between 24-hour protein excretion and the random urine protein-creatinine ratio (r(s)=0.596, P < .01). With a cut-off protein-creatinine ratio greater than 1.14 as a predictor of significant proteinuria, sensitivity and specificity were 72% and 75%, respectively. The positive predictive value was 94.9% and negative predictive value was 29.2%. CONCLUSION: The random urine protein-creatinine ratio was not a good predictor of significant proteinuria in patients with preeclampsia.
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