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  • Title: Combined effect of gender and caloric restriction on liver proteomic expression profile.
    Author: Valle A, Silvestri E, Moreno M, Chambery A, Oliver J, Roca P, Goglia F.
    Journal: J Proteome Res; 2008 Jul; 7(7):2872-81. PubMed ID: 18505282.
    Abstract:
    We analyzed the combined effect of gender and CR on protein expression profile in liver. We identified 27 differentially expressed proteins involved in several cellular functions such as substrate metabolism, antioxidant systems, stress response, iron homeostasis and cardiovascular protection. This study reveals new cellular pathways liable to be similarly regulated in females and calorie restricted rats and which could be related with the greater longevity in these animals.
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