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  • Title: Molluscicidal activity of 2-hydroxy-[1,4]naphthoquinone and derivatives.
    Author: Camara CA, Silva TM, da-Silva TG, Martins RM, Barbosa TP, Pinto AC, Vargas MD.
    Journal: An Acad Bras Cienc; 2008 Jun; 80(2):329-34. PubMed ID: 18506259.
    Abstract:
    The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 microg/mL set for potential molluscicidal activity by the World Health Organization. As a general rule derivatives with non-polar substituents presented the highest molluscicidal activities. These substances showed significant toxicity in A. salina lethality bioassay.
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