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  • Title: Fundus autofluorescence related to retinal morphological and functional changes in idiopathic macular holes.
    Author: Wakabayashi T, Ikuno Y, Sayanagi K, Soga K, Oshima Y, Tano Y.
    Journal: Acta Ophthalmol; 2008 Dec; 86(8):897-901. PubMed ID: 18507731.
    Abstract:
    PURPOSE: To investigate fundus autofluorescence (FAF) characteristics in relation to morphological and functional features of idiopathic macular hole (IMH). METHODS: Twenty eyes of 20 consecutive patients with stage 3 or 4 macular holes were included. Fundus autofluorescence images were obtained using the Heidelberg retina angiograph 2, retinal structure was evaluated with 3-dimensional (3-D) imaging of Fourier-domain optical coherence tomography (FD-OCT), and retinal function was assessed with microperimetry-1 (MP-1). RESULTS: Markedly increased FAF in the foveal centre corresponding to the macular hole, confirmed with FD-OCT, was demonstrated in all eyes. A surrounding hypoautofluorescent ring corresponded to the subretinal fluid cuff. The area of relatively reduced FAF around the ring corresponded precisely to retinal oedema. In 15 eyes (75%), a stellate appearance with dark radiating striae was seen in the relatively reduced FAF and was correlated with intraretinal cystic changes in the outer plexiform layer, observed by FD-OCT. Mean preoperative visual acuity was significantly poorer in eyes without a stellate appearance than in those with a stellate appearance (p = 0.023). The MP-1 study confirmed impaired retinal function in the macular hole bed and in the area of the fluid cuff and retinal oedema. CONCLUSIONS: Fundus autofluorescence imaging reflects anatomic changes and represents the dysfunctional retinal area in IMH. The technique provides 2-D images with 3-D information on the retinal morphology of this disease.
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