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  • Title: Hormonal and nutritional control of L-carnitine uptake in myoblastic C2C12 cells.
    Author: Le Borgne F, Rigault C, Georges B, Demarquoy J.
    Journal: Muscle Nerve; 2008 Jul; 38(1):912-5. PubMed ID: 18508344.
    Abstract:
    L-Carnitine plays an important role in skeletal muscle bioenergetics, and its bioavailability and thus its import may be crucial for muscle function. We studied the effect of thyroid hormone, insulin, and iron overload, hormones and nutrients known to alter muscle metabolism, on L-carnitine import into C2C12 cells. We report here L-carnitine uptake is increased by thyroid hormones and decreased by iron. Insulin was found to be ineffective in altering the L-carnitine uptake.
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