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  • Title: Successive copper(I)-catalyzed cross-couplings in one pot: a novel and efficient starting point for synthesis of carbapenems.
    Author: Jiang B, Tian H, Huang ZG, Xu M.
    Journal: Org Lett; 2008 Jul 03; 10(13):2737-40. PubMed ID: 18510330.
    Abstract:
    An efficient approach for synthesizing a series of 2-sulfide carbapenems has been developed using two successive Cu(I)-catalyzed cross-couplings in a single pot. The method involves highly selective intramolecular coupling of lactam and dihaloalkene using 2,2'-bipyridine as a ligand, followed by intermolecular C-S formation in the presence of another ligand (1,10-phenanthroline, PPh 3) and mercaptan.
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