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  • Title: p53 regulation orchestrates the TGF-beta response.
    Author: Piccolo S.
    Journal: Cell; 2008 May 30; 133(5):767-9. PubMed ID: 18510920.
    Abstract:
    Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target genes that promote mesoderm specification.
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