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  • Title: Peripheral neuropathy in cold agglutinin disease.
    Author: Thomas TD, Donofrio PD, Angelo J.
    Journal: Muscle Nerve; 1991 Apr; 14(4):331-4. PubMed ID: 1851246.
    Abstract:
    Cold agglutinin disease (CAD) characteristically presents as anemia and cold-induced rash. We report a man with purpura, anemia, cold agglutinins, and a sensory-autonomic polyneuropathy. Treatment with corticosteroids and plasma exchange resulted in resolution of the anemia and polyneuropathy. We propose that CAD may be associated with a reversible sensory-autonomic neuropathy in the absence of cryoglobulinemia. Although unsupported by pathologic findings, pathogenetic hypotheses for the neuropathy in CAD are similar to those proposed for cryoglobulinemic neuropathy.
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