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  • Title: Prenatal stress and epilepsy in later life: a nationwide follow-up study in Denmark.
    Author: Li J, Vestergaard M, Obel C, Precht DH, Christensen J, Lu M, Olsen J.
    Journal: Epilepsy Res; 2008 Sep; 81(1):52-7. PubMed ID: 18514486.
    Abstract:
    PURPOSE: To examine whether prenatal exposure to maternal bereavement is associated with an increased risk of epilepsy in the first decades of life. METHODS: We conducted a population-based cohort study of children (N=1,553,966) born in Denmark from 1978 to 2004. A total of 39,867 children born to women who lost a close relative while pregnant or within 1 year before the pregnancy were included in the exposed cohort. The main outcome of interest was hospitalization due to epilepsy (ICD 8 codes 345.00-345.99, ICD 10 codes G40.0-G41.9). We used log-linear Poisson models to estimate incidence rate ratios (IRRs). RESULTS: The exposed children had a risk of epilepsy similar to that of unexposed children (IRR 1.06, 95% CI 0.96-1.18). The IRRs were 1.08 (95% CI 0.89-1.31) for the children of women who lost a child, and 1.02 (95% CI 0.91-1.15) for the children of women who lost a partner, parent or sibling. The IRRs did not differ according to the timing of exposure or the causes of death (unexpected causes and other causes). CONCLUSIONS: Our data do not suggest any strong association between prenatal stress and epilepsy in the first decades of life.
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