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  • Title: Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides.
    Author: Lougiakis N, Marakos P, Pouli N, Balzarini J.
    Journal: Chem Pharm Bull (Tokyo); 2008 Jun; 56(6):775-80. PubMed ID: 18520079.
    Abstract:
    The preparation of novel 5-amino or 7-hydroxy substituted pyrazolo[4,3-b]pyridine and pyrazolo[3,4-c]pyridine acyclic C-nucleosides is described. Their synthesis was carried out by condensation of suitably substituted lithiated picolines with 2-benzyloxyethoxymethylchloride followed by pyrazole ring annulation. The compounds were evaluated for their antiviral activity against a wide panel of viruses, but were found inactive at subtoxic concentrations.
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