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  • Title: Ameliorating effect of balloon flower saponin on the ethanol-induced memory impairment in mice.
    Author: Choi YH, Kim YS, Yeo SJ, Roh SH, Jeong YC, Kang JS, Ryu SY.
    Journal: Phytother Res; 2008 Jul; 22(7):973-6. PubMed ID: 18521966.
    Abstract:
    The ameliorating effect of the root extract of Platycodon grandiflorum (Campanulaceae) on ethanol-induced cognitive dysfunction in mice was investigated. The mice with repeated administration of the root extract of P. grandiflorum, crude saponin fraction and platycoside E, a main ingredient of crude saponin fraction, showed a markedly prolonged step-through latency period (STL) on the passive avoidance task performed after acute ethanol intoxication, respectively. The present results suggest that the memory enhancing effect of the extract was ascribed mainly to the saponin fraction and that saponin of P. grandiflorum, particularly platycoside E could exert a beneficial effect on memory impairment in mice.
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