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  • Title: [T-and B-cell immune response of lymph nodes and immunosuppression correlating with metastatic spread of stomach cancer].
    Author: Bugrov VV, Absaliatova OV, Savkova RF, Kozlova NM.
    Journal: Vopr Onkol; 2008; 54(2):216-9. PubMed ID: 18522173.
    Abstract:
    A correlation was established in 708 stomach cancer patients between number of involved lymph nodes, on the one hand, and T- and B-cell immune response and morphological tumor pattern, on the other. That in turn significantly correlated with T-cell immune response and tumor localization. However, B-cell immune response and tumor size showed an inverse and less pronounced correlation with number of involved lymph nodes. Immunosuppression and metastatic spread are inter-connected; both quickly develop in succession in a node nearest to tumor and then continue invade. Immunosuppression is induced by tumor cytokines and innate regulatory T-cells which can either suppress or stimulate immune response, irrespective of tumor size.
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