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  • Title: Chemical characterization of ectopic ACTH purified from a malignant thymic carcinoid tumor.
    Author: Lowry PJ, Rees LH, Tomlin S, Gillies G, Landon J.
    Journal: J Clin Endocrinol Metab; 1976 Oct; 43(4):831-5. PubMed ID: 185233.
    Abstract:
    ACTH was purified from thymic tumor associated with ectopic ACTH production by gel filtration and ion exchange chromatography. Amino acid composition and C- and N-terminal analyses indicated that this tumor ACTH was comprised of the 2-38 sequence of authentic pituitary ACTH. The observations suggest that the mode of cleavage of this tumor ACTH from its precursor is different from that of pituitary ACTH.
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