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  • Title: Optimal allocation of pandemic influenza vaccine depends on age, risk and timing.
    Author: Mylius SD, Hagenaars TJ, Lugnér AK, Wallinga J.
    Journal: Vaccine; 2008 Jul 04; 26(29-30):3742-9. PubMed ID: 18524428.
    Abstract:
    The limited production capacity for vaccines raises the question what the best strategy is for allocating the vaccine to mitigate an influenza pandemic. We developed an age-structured model for spread of an influenza pandemic and validated it against observations from the Asian flu pandemic. Two strategies were evaluated: vaccination can be implemented at the start of the influenza pandemic, or vaccination will be implemented near the peak of it. Our results suggest prioritizing individuals with a high-risk of complications if a vaccine becomes available during a pandemic. If available at the start, vaccinating school children might be considered since this results in slightly lower expected number of deaths.
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