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  • Title: Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.
    Author: Liang GB, Qian X, Biftu T, Singh S, Gao YD, Scapin G, Patel S, Leiting B, Patel R, Wu J, Zhang X, Thornberry NA, Weber AE.
    Journal: Bioorg Med Chem Lett; 2008 Jul 01; 18(13):3706-10. PubMed ID: 18524582.
    Abstract:
    Probing with tool molecules, and by modeling and X-ray crystallography the binding modes of two structurally distinct series of DPP-4 inhibitors led to the discovery of a rare aromatic fluorine H-bond and the spatial requirement for better biaryl binding in the DPP-4 enzyme active site. These newly found binding elements were successfully incorporated into novel DPP-4 inhibitors.
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