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  • Title: Development of a novel fluorescent probe for fluorescence correlation spectroscopic detection of kinase inhibitors.
    Author: Kawaguchi M, Terai T, Utata R, Kato M, Tsuganezawa K, Tanaka A, Kojima H, Okabe T, Nagano T.
    Journal: Bioorg Med Chem Lett; 2008 Jul 01; 18(13):3752-5. PubMed ID: 18524589.
    Abstract:
    We have developed a fluorescently labeled probe for high-throughput screening of kinase inhibitors using fluorescence correlation spectroscopy. With this probe, we have successfully evaluated the inhibitory activities of known inhibitors of a model kinase, ASK1. Because the probe contains a general kinase inhibitor, staurosporine, we believe that this homogeneous, high-throughput, and simple method can be applied to the inhibitor screening of other kinases as well.
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