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  • Title: Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.
    Author: Colabufo NA, Berardi F, Contino M, Inglese C, Niso M, Perrone R.
    Journal: Bioorg Med Chem Lett; 2008 Jul 01; 18(13):3741-4. PubMed ID: 18524592.
    Abstract:
    Several reference compounds such as Cyclosporin A, Tamoxifen, Verapamil, and our compound 1, known as P-gp modulators, have been tested for their P-gp modulating activity in isolated organ bath. Compound 1 showed the best result in organ bath experiment (EC(50)=14.7 microM), Cyclosporin A and Tamoxifen displayed EC(50)=25.2 and 39.4 microM, respectively.
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