These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A facile Zr-mediated multicomponent approach to arylated allylic alcohols and its application to the synthesis of highly substituted indenes and spiroindenes.
    Author: Guo S, Liu Y.
    Journal: Org Biomol Chem; 2008 Jun 21; 6(12):2064-70. PubMed ID: 18528567.
    Abstract:
    An efficient and one-pot procedure for the synthesis of arylated and stereodefined allylic alcohols has been achieved through zirconium-mediated multicomponent coupling reactions of alkynes, aldehydes (or ketones), and aryl iodides. The subsequent intramolecular Friedel-Crafts reactions of these allylic alcohols catalyzed by Brønsted or Lewis acids afford highly substituted indenes and spiroindenes under extremely mild reaction conditions. This methodology also provided a highly efficient route to the synthesis of spiroindenepiperidines.
    [Abstract] [Full Text] [Related] [New Search]