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  • Title: Interaction of methimazole with I2: X-ray crystal structure of the charge transfer complex methimazole-I2. implications for the mechanism of action of methimazole-based antithyroid drugs.
    Author: Isaia F, Aragoni MC, Arca M, Demartin F, Devillanova FA, Floris G, Garau A, Hursthouse MB, Lippolis V, Medda R, Oppo F, Pira M, Verani G.
    Journal: J Med Chem; 2008 Jul 10; 51(13):4050-3. PubMed ID: 18529045.
    Abstract:
    The antithyroid drug methimazole (MMI) reacts with molecular iodine to form, in a multistep process, 1-methylimidazole as final product. In this process, the charge transfer complex MMI-I 2 and the ionic disulfide [(C 4H 6N 2S-) 2] (2+) ( 1, dication MMI disulfide) have been isolated and their X-ray crystal structures solved. Dication MMI disulfide perchlorate acts effectively both in reducing I 2 to I (-) ions and in showing antioxidant properties in inactivating the enzyme lactoperoxidase compound I.
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