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  • Title: [Effect of triptergium wilfordii polyglycosidium on content of Th1 and Th2 in child recurrent nephrotic syndrome].
    Author: Hu GH, Yi ZW, Wang JH, Yao JC.
    Journal: Zhongguo Zhong Yao Za Zhi; 2008 Feb; 33(4):441-3. PubMed ID: 18533507.
    Abstract:
    OBJECTIVE: To study the effect of triptergium wilfordii polyglycosidium on the content of Th1 and Th2 in the treatment child patients of rcurrent nephrotic syndrome. METHOD: Patients were randomized into treatment group and health group. Sixty-one patients in treatment group were treated with triptergium wilfordii polyglycosidium 1 mg x kg(-1) x d(-1) orally tid for 12 weeks. However, patients in health group was not treated with any drugs. Twelve weeks constituted one course of treatment and the content of IL-12, IL-2, TNF-alpha, IL-13, IL-6, IL-4 in peripheral blood was measured before and behind therapy. RESULT: In treatment group, the content of serum cytokines behind therapy was significantly lower than that before therapy, except for IL-12. CONCLUSION: Triptergium wilfordii polyglycosidium could reduce the cytokine level (except for IL-12) of Th1 and Th2, which could lead a therapeutic effect of in the child patients of RNS.
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