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  • Title: Alterations in DNA, RNA and protein contents in liver and kidney of mice treated with ochratoxin and their amelioration by Emblica officinalis aqueous extract.
    Author: Verma R, Chakraborty D.
    Journal: Acta Pol Pharm; 2008; 65(1):3-9. PubMed ID: 18536167.
    Abstract:
    The present investigation was an attempt to study ameliorative effect of Emblica officinalis aqueous extract on ochratoxin-induced toxicity on DNA, RNA and protein contents in liver and kidney of mice. Adult male albino mice were orally administered with 50 and 100 microg of ochratoxin/0.2 mL of olive oil/animal/day for 45 days. The results revealed significant (p < 0.05), dose-dependent decrease in the concentrations of DNA, RNA as well as total, acidic, basic and neutral protein contents in the liver and kidney of ochratoxin-treated mice. Administration of Emblica officinalis aqueous extract (2 mg/animal/day) for 45 days along with ochratoxin caused significant amelioration in the ochratoxin-induced reduction in DNA, RNA and protein contents in the liver and kidney of mice.
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