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  • Title: [Influence of the treatment of chronic hepatitis B on HBV DNA suppression and prevention of disease progression].
    Author: Pawłowska M.
    Journal: Przegl Epidemiol; 2008; 62(1):139-42. PubMed ID: 18536236.
    Abstract:
    Appropriate treatment for chronic hepatitis B to present disease progression and clinical complications requires an accurate knowledge of the natural history of this disorder. The natural course of chronic HBV infections now perceive as consisting of 4 phases: immune tolerance, immune clearance, inactive carrier state and reactivation. In patients who acquire the disease in early life complications of CHB continue to develop because of the prolonged insidious damage to the liver. Measurement of serum HBV DNA is the most important factor to evaluate disease activity, assess the efficacy of antiviral therapy and predict treatment outcomes. It was shown that higher HBV DNA levels are associated with increased risk of progression to cirrhosis and HCC. Long-term suppression of viral replication to very low levels with nucleoside (nucleotide) analogues has been shown to decrease or delay liver disease progression and even partially reverse preexisting fibrosis and cirrhosis.
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