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  • Title: Clinical remission and histopathological resolution of nodular lesions in a patient with gamma3 heavy-chain deposition disease.
    Author: Soma J, Tsuchiya Y, Sakuma T, Sato H.
    Journal: Clin Nephrol; 2008 May; 69(5):383-6. PubMed ID: 18538103.
    Abstract:
    Heavy-chain deposition disease (HCDD) is a rare entity accompanying to nonamyloidotic monoclonal immunoglobulin deposition disease. We report a case of gamma3-HCDD in which follow-up biopsy could be done after complete remission was achieved by chemotherapy. Follow-up biopsy 2 years after initial biopsy showed remarkable diminution of both nodular glomerular lesions and IgG heavy-chain deposits. This is the first case report to indicate that the original structure of glomeruli in patients with HCDD could be restored within a few years by an appropriate treatment at an early stage of the disease.
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