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  • Title: Oral mizoribine pulse therapy for steroid-dependent focal segmental glomerulosclerosis.
    Author: Doi T, Masaki T, Shiraki N, Kawai T, Yorioka N.
    Journal: Clin Nephrol; 2008 Jun; 69(6):433-5. PubMed ID: 18538119.
    Abstract:
    A 24-year-old woman with focal segmental glomerulosclerosis was referred to our hospital for treatment of nephrotic syndrome. Though she experienced partial remission following treatment with prednisone and cyclosporine, she had a relapse of nephrotic syndrome when her prednisone was tapered off to 30 mg/day. The prednisone could not be tapered to less than 30 mg/day due to repeated relapses. After introduction of oral mizoribine (MZR) pulse therapy, the patient's prednisone was tapered to 15 mg/day and she had no signs of relapse for more than 1 year. This case suggests that oral MZR pulse therapy is a good therapeutic option for patients with steroid-dependent nephrotic syndrome.
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