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  • Title: Xanthogranulomas associated with hematologic malignancy in adulthood.
    Author: Shoo BA, Shinkai K, McCalmont TH, Fox LP.
    Journal: J Am Acad Dermatol; 2008 Sep; 59(3):488-93. PubMed ID: 18538449.
    Abstract:
    Although xanthogranulomatosis (XG), defined as multiple xanthogranulomas occurring simultaneously, was originally described in infants and children, a number of adult cases have been reported. Adult XG, which generally presents in the absence of hyperlipidemia, has many similarities to the childhood variant. Among the similarities are reports of the simultaneous development of XG and hematologic disorders. Herein we report a case of XG in a 45-year-old man with B-cell acute lymphoblastic leukemia and review the literature regarding the association of XG and hematologic disorders in adults. We propose that xanthogranulomas seen in children and adults bear many similarities, clinically and histopathologically, and share an association with hematologic malignancies.
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