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  • Title: Oral immunization with Salmonella harboring a Sm14-based DNA vaccine does not protect mice against Schistosoma mansoni infection.
    Author: Pacheco LG, Mati VL, Castro TL, Dorella FA, Oliveira SC, Miyoshi A, de Melo AL, Azevedo V.
    Journal: Parasitol Int; 2008 Dec; 57(4):506-8. PubMed ID: 18538627.
    Abstract:
    The protection against Schistosoma mansoni infection was evaluated in SWISS mice orally vaccinated with an attenuated strain of Salmonella carrying a Sm14-based DNA vaccine. Although this formulation was not able to afford a reduction in the worm burden, a non-antigen-specific decrease in schistosome-induced granulomatous reaction was verified in livers of mice that received Salmonella.
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