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  • Title: [Histopathologic pattern of hyperplasia of bone marrow hematogones (medullar b lymphoid cell precursors) occurring after treatment of idiopathic myelofibrosis].
    Author: Lebwaze BM, Le Tourneau A, Rio B, Perrot JY, Heuberger L, Kabongo JM, Kalengayi RM, Molina T, Diebold J, Audouin J.
    Journal: Ann Pathol; 2008 Feb; 28(1):27-31. PubMed ID: 18538711.
    Abstract:
    Hematogones are bone marrow precursors of B-lymphoid cells which are morphologically difficult to distinguish from blasts and/or from small lymphocytes. We report the case of a patient presenting idiopathic myelofibrosis with minimal myeloid blastic transformation causing severe pancytopenia, treated by allograft and showing in a bone marrow biopsy, a hyperplasia of B-lymphoid cells. Histopathology and immunohistochemistry identified these cells as hyperplasia of hematogones and not a transformation into lymphoblastic acute leukaemia. The cytology of a myelogram confirmed the diagnosis.
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