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  • Title: Hyporegenerative anemia associated with intrauterine transfusion in rhesus hemolytic disease.
    Author: Thorp JA, O'Connor T, Callenbach J, Cohen GR, Yeast JD, Albin J, Plapp F.
    Journal: Am J Obstet Gynecol; 1991 Jul; 165(1):79-81. PubMed ID: 1853921.
    Abstract:
    Serial erythropoietin and ferritin levels were monitored in a fetus and newborn requiring three intravascular transfusions (in utero) for severe Rh disease. The newborn had a hematocrit of 37% at birth; however a hyporegenerative transfusion-dependent anemia developed and lasted approximately 3 months. The prolonged hyporegenerative anemia may be caused in part by erythropoietin suppression as a result of the fetal intravascular transfusions. In addition, anti-D antibody may also contribute to this anemia by a direct toxic effect on erythroid precursors and by peripheral hemolysis of reticulocytes.
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