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  • Title: Microscopic and macroscopic evaluation of emboli captured during angioplasty and stent procedures in extracranial vertebral and internal carotid arteries.
    Author: Divani AA, Berezina TL, Zhou J, Pakdaman R, Suri MF, Qureshi AI.
    Journal: J Endovasc Ther; 2008 Jun; 15(3):263-9. PubMed ID: 18540698.
    Abstract:
    PURPOSE: To compare the quantities of emboli dislodged during percutaneous transluminal angioplasty/stenting in the vertebral artery (VA) with those released during stent placement in the internal carotid artery (ICA). METHODS: Macroscopic images of distal protection devices (DPD) used during 30 stent procedures in 16 ICAs (11 men; mean age 64.6+/-10.6 years) and 14 VAs (9 men; mean age 67.1+/-9.8 years) were reviewed. The amount of captured embolic debris was calculated and expressed as a proportion to the size of the filter. Histological examinations were performed to characterize the material trapped in the filters. RESULTS: Relative to the size of the filter, the proportion of captured debris ranged from 0.1% to approximately 22% in the ostial VA filters and from 0.1% to approximately 21% in the filters used in the ICA procedures (p = NS). Plaque fragments with or without thrombus were discovered in the histological examinations of captured material. There were no significant differences in the characteristics of the debris between the 2 vascular regions, nor did sex, race, or plaque morphology correlate significantly with the proportion of captured debris. However, the severity of stenosis was significantly (p<0.029) greater in the ICA (73%+/-0.11%) than the VA (63%+/-0.09%) territory. CONCLUSION: The study suggests that the frequency and amount of captured emboli during stent procedures in ICA and ostial VAs are comparable. Therefore, the use of a DPD for stent placement in the vertebral artery may be advisable.
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