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  • Title: Sex differences in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects.
    Author: Frank J, Lee S, Leonard SW, Atkinson JK, Kamal-Eldin A, Traber MG.
    Journal: Am J Clin Nutr; 2008 Jun; 87(6):1723-9. PubMed ID: 18541561.
    Abstract:
    BACKGROUND: Gamma-tocopherol has unique properties that may be beneficial in sustaining optimal human health, but hepatic vitamin E metabolism enhances gamma-tocopherol turnover. OBJECTIVE: Our aim was to determine the extent to which dietary sesame lignans alter human alpha- and gamma-tocopherol metabolism and elimination as carboxyethyl hydroxychromanols (CEHCs). DESIGN: Healthy participants (n = 5 women and 5 men) in a randomized, crossover study (with 4-wk washout) consumed muffins prepared with either corn oil or unrefined sesame oil (sesamin, 94 mg; sesamolin, 42 mg), along with a capsule containing a 1:1 molar ratio of deuterium-labeled d(6)-alpha- and d(2)-gamma-tocopherol acetates ( approximately 50 mg each). Plasma and urine were collected up to 72 h; unlabeled and labeled tocopherol and CEHC concentrations were determined by liquid chromatography-mass spectrometry. RESULTS: Sesame oil muffin consumption in men, but not in women, decreased (P < 0.05) areas under plasma d(2)-gamma-CEHC concentration-time curves (area under the curve) and maximum concentrations. However, in both sexes urinary d(2)-gamma-CEHCs were decreased for 24 h following sesame oil muffin consumption. CONCLUSIONS: In humans, gamma-tocopherol metabolism can be inhibited by the simultaneous consumption of gamma-tocopherol and sesame lignans. The observed differences between men and women with respect to vitamin E metabolism warrant further investigation.
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