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  • Title: [Orange-red light reduces the inhibition by UV-A of the proliferation of rat fibroblasts and influences their attachment in a dose-dependent fashion].
    Author: Khramov RN, Katkov IuA, Kreslavskiĭ VD, Murashev AN, Tsyganova VG, Simonova NB, Manokhin AA.
    Journal: Biofizika; 2008; 53(2):294-8. PubMed ID: 18543771.
    Abstract:
    The effects of ultraviolet-A (UV-A, lambdam = 365 nm) and orange-red light (lambdam = 625 nm) on the attachment and proliferation of embryonic skin-muscle rat fibroblasts were investigated. It was found that orange-red light (ORL) produces both the stimulatory and inhibitory actions on the attachment and proliferation of fibroblasts, whereas UV-A radiation caused only the inhibition of the processes. Upon consecutive irradiation in both variants: ORL --> UV and UV --> ORL, the synergistic effect of the inhibitory action in both spectral regions was observed. Conversely, upon simultaneous irradiation with ORL (dose 3.6 J/cm2) and UV-A (dose 1.8 J/cm2), the inhibitory effect of ORL and UV-A weakened. Possible mechanisms of the effects are analyzed.
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