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  • Title: Mollamides B and C, Cyclic hexapeptides from the indonesian tunicate Didemnum molle.
    Author: Donia MS, Wang B, Dunbar DC, Desai PV, Patny A, Avery M, Hamann MT.
    Journal: J Nat Prod; 2008 Jun; 71(6):941-5. PubMed ID: 18543965.
    Abstract:
    Two new cyclic hexapeptides, mollamides B (1) and C (2), were isolated from the Indonesian tunicate Didemnum molle along with the known peptide keenamide A (3). The structures were established using 1D and 2D NMR experiments. The relative configuration of mollamide B at the thiazoline moiety was determined using molecular modeling coupled with NMR-derived restraints. Their absolute configuration was determined using Marfey's method. The new peptides have been evaluated for their antimicrobial, antimalarial, anticancer, anti-HIV-1, anti-Mtb, and anti-inflammatory activities. Keenamide A and mollamide B show cytotoxicity against several cancer cell lines.
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