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  • Title: Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034.
    Author: Bogen S, Arasappan A, Pan W, Ruan S, Padilla A, Saksena AK, Girijavallabhan V, Njoroge FG.
    Journal: Bioorg Med Chem Lett; 2008 Jul 15; 18(14):4219-23. PubMed ID: 18547808.
    Abstract:
    Substitutions on the P(1) cyclobutyl side chain of SCH 503034 were studied by introduction of hydroxyl and fluoro substituents. Additionally, effects of fluoro substitution on other P1 moieties were evaluated.
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