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  • Title: Regulation of Cl-dependent K transport by oxy-deoxyhemoglobin transitions in trout red cells.
    Author: Borgese F, Motais R, García-Romeu F.
    Journal: Biochim Biophys Acta; 1991 Jul 22; 1066(2):252-6. PubMed ID: 1854788.
    Abstract:
    The oxygenation of trout red cells opens a Cl-dependent K pathway inhibited by furosemide, and by inhibitors of the erythrocyte anion exchanger such as DIDS and niflumic acid. The trigger is the deoxy-oxy conformational change of hemoglobin. The binding of carbon monoxide to heme, which induces a similar conformational change, mimics the effect of oxygen. The possible mechanisms enabling molecular oxygen to control the transport protein are discussed. This oxygenation-activated K transport appears to play a regulatory role in the control of the extracellular K concentration.
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