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  • Title: [The effect of microinjections of morphine and tramadol into the locus coeruleus on the nociceptive responses of the spinal cord neurons and on shifts in the arterial pressure].
    Author: Kolchin VV, Zaĭtsev AA.
    Journal: Biull Eksp Biol Med; 1991 Feb; 111(2):126-8. PubMed ID: 1854949.
    Abstract:
    Morphine and tramadol produces selective inhibition of the spinal noxious-evoked activity, but does not change blood pressure reactions. Antinociception was reversed by this structure injection of the naloxone. These data suggest that locus coeruleus realized the pain-relief effect of the opiate drugs.
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