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  • Title: [The functional-morphological state of the myocardium in experimental massive embolism of the pulmonary artery].
    Author: Karpova VV, Tverskaia MS, Virganskiĭ AO, Banin VV, Tikhvinskaia EI, Satylganov IZh, Chumakova MA, Rogulenko RV.
    Journal: Biull Eksp Biol Med; 1991 Feb; 111(2):130-2. PubMed ID: 1854950.
    Abstract:
    A comparative study of hemodynamic and structural-metabolic changes in the myocardium of the right (RV) and left ventricles (LV) in acute massive pulmonary artery embolism was made in 19 mongrel dogs. In the control group the activity of SDH, MDH, GDH, NADH-DH in LV were higher than in RV. The numeral density and relative area of mitochondrial profile surface in LV was higher that in RV. A significant increase in afterload on RV causes intensification of cell respiration, a rise in numeral density and relative area of mitochondrial profile surface. Weakening of LV work leads to contrary structural-metabolic changes. Thus, contrary changes in hemodynamic loads on RV and LV in acute compensative massive pulmonary artery embolism correlated with contrary changes in their cell metabolism.
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