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  • Title: [The significance of chorionic gonadotropin in regulating the antigen-independent differentiation of immunocompetent splenic cells].
    Author: Shirshev SV.
    Journal: Biull Eksp Biol Med; 1991 Feb; 111(2):181-3. PubMed ID: 1854965.
    Abstract:
    The functional activity of fractionated splenocytes were investigated in the syngeneic transfer system. Chorionic gonadotrophin (CG) was injected to ovariectomized and noncastrated lymphocyte donors, the T or B lymphocytes being isolated on a column with a nylon fiber and by means of anti-BaO-serum accordingly. In some series CG was introduced only into recipients before their being irradiated and before syngeneic cells transferring. CG has been stated to be capable of influencing either independently or by means of ovarian hormones splenic B lymphocytes without exhibiting a significant effect on T helper precursors as well as radioresistant cells of the splenic stroma. The character of immunoregulating effect was completely dependent on the presence of ovaries in mice and on the hormone dose.
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