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  • Title: [The function of the liver mitochondria in rats with experimental cirrhosis undergoing an organ-preserving operation on the spleen].
    Author: Aliev MM, Leont'ev AF, Karimov KhIa, Inoiatova FKh.
    Journal: Biull Eksp Biol Med; 1991 Feb; 111(2):191-3. PubMed ID: 1854969.
    Abstract:
    The effect of splenectomy and of spleen-preserving operation with suture ligation of the left gastric artery on the functional status of liver mitochondria was studied by using 102 white male-rats of mixed population with experimental cirrhosis. The obtained data made it evident that in the immediate postoperative period (from 1 to 3 weeks after the procedure) in the animals of both the first and the second series, the disorder of energetic regulation of mitochondria hepatocytes respiration and the decrease in phosphorylation efficiency had the same tendency, which were seemingly caused by stress-action of the operative trauma. The data accumulated in the more distant postoperative period (8 weeks after the procedure) indicated that the resection of the lower splenic pole in combination with supplementary liver arterialization improved essentially the functional status of mitochondria hepatocytes and was more beneficial in contradistinction to splenectomy.
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