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  • Title: Long-term biomonitoring of polychlorinated biphenyls and organochlorine pesticides in human milk from mothers living in northern Germany.
    Author: Zietz BP, Hoopmann M, Funcke M, Huppmann R, Suchenwirth R, Gierden E.
    Journal: Int J Hyg Environ Health; 2008 Oct; 211(5-6):624-38. PubMed ID: 18550430.
    Abstract:
    Polychlorinated biphenyls (PCBs) and organochlorine pesticides are persistent organic pollutants that have a widespread distribution in the environment. Human biomonitoring is a suitable tool to assess the burden of humans with these substances. Over a time span of 8 years, a free analysis of their milk was offered to lactating mothers residing in the state of Lower Saxony, Germany. The human milk was analyzed for a number of organic chemicals including polychlorinated biphenyls (PCBs), 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), hexachlorobenzene (HCB) and beta-hexachlorocyclohexane (beta-HCH). Factors that may influence these levels were investigated using a questionnaire. In total, 4314 samples were collected in the years 1999-2006 and analyzed for their content of these persistent organic pollutants (POPs). A clear downward trend of median total PCB, DDT, beta-HCH and HCB values in all participants and also in different selected subgroups could be observed. The median values of calculated total PCB in the year 2006 including all participants was 0.1825mg/kg lipid, that of DDT 0.0815mg/kg lipid, beta-HCH 0.0116mg/kg lipid and of HCB 0.0229mg/kg lipid. There were reductions between 40.9% and 47.1% compared to the year 1999. Among other influencing factors, median concentrations of total PCB, DDT, beta-HCH and HCB showed a clear rise with increasing age of mothers whereas an increasing number of breastfed infants per mother led to a decrease. The proportions of other measured substances exceeding limits of quantification were as follows: dieldrin 68.6%, alpha-HCH 1.3%, gamma-HCH 60.1%, heptachlor epoxide 41.5%, musk xylene 15.6%, musk ambrette 0.4%. We conclude that the known declining trend of important xenobiotic substances in human milk of German mothers has continued.
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