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  • Title: Angiotensin II receptor subtypes in rat brain: dithiothreitol inhibits ligand binding to AII-1 and enhances binding to AII-2.
    Author: Gehlert DR, Gackenheimer SL, Schober DA.
    Journal: Brain Res; 1991 Apr 12; 546(1):161-5. PubMed ID: 1855146.
    Abstract:
    Angiotensin II (AII) receptor subtypes have been proposed on the basis of the selectivity of non-peptide AII antagonists. In the present study, the sulfhydryl reducing agent dithiothreitol (DTT) was found to reduce binding to the AII-1 receptor while enhancing binding at the AII-2 site. The neuroanatomical distribution of these effects were consistent with the distribution of AII-1 and AII-2 receptors, respectively. These data indicate that AII receptor subtypes in the brain can be differentiated by both biochemical and pharmacological means.
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